RE: Pamela's in Pittsburgh: Strip District location?
They are all related and as far as I know, they have the same menu. This is my favorite location to eat at, since it is the closest to my house. I also believe it has the largest seating capacity (the Oakland location has quite a few seats, too) and just may be the easiest one to get into. But expect a short wait on a weekend morning regardless. The strawberry hotcakes (and other things) make it very much worth it!
The most difficult location to get into, in my experience, is the Shadyside location. I have had some really long waits there, before.