RE: SC to Palatka, FL
In Palatka, on the main street, on the south end of town. on your right going south is a good BB joint. Sorry, can't remember the name, but we had good ribs and pulled pork sandwich there this past Winter.
In the Palatka area look for fried catfish - the tiny ones they fry up whole - not the filets. They're worth the trip!
If you have a taste for gator and cooter there are several places along the St Johns that are well known for those items. Our friends who live in the area took us to a couple of places and I was lost and do not know the names. Personally, now that I've had gator and cooter, I can live without them ...
In Georgia take the Pooler exit ( about 15 miles south of the SC border) , drive about one mile into Pooler and stop at Dons Famous BBQ on your left - it's great pulled pork!